From: Subject: Chronic Pain Is in the Brain, not in the Injury - Treating the emotions of the pain - Softpedia Date: Tue, 1 Apr 2008 17:48:39 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_01A6_01C89420.9E1FD610" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_01A6_01C89420.9E1FD610 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://news.softpedia.com/news/Chronic-Pain-is-the-Brain-Memory-not-in-the-Injury-56567.shtml Chronic Pain Is in the Brain, not in the Injury - = Treating the emotions of the pain - Softpedia

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Chronic=20 Pain Is in the Brain, not in the Injury

-=20 Treating the emotions of the pain

By:=20 Stefan Anitei, Science Editor

=0A=

Enlarge = picture

Chronic pain can=20 make your life miserable long after your injuries have = actually healed. Standard analgesic drugs, like = aspirin and=20 morphines, are largely ineffective.

Vania = Apkarian,=20 professor of physiology and of anesthesiology, at=20 Northwestern=92s Feinberg School of Medicine, revealed = that=20 chronic pains can be old memory remains stuck in the=20 prefrontal cortex, linked to emotion and learning: the = brain=20 still remembers the injury as if it were fresh and = can=92t erase=20 it. Apkarian has found a drug that works on the part = of the=20 brain which is linked to the emotional suffering of = pain.=20

=0A=

D-Cycloserine has been used against phobic = behavior in=20 the last 10 years and animal trials showed that = D-Cycloserine=20 significantly decreased the emotional suffering from = pain but=20 also sensitivity of the formerly injured site and = nerve pain=20 resulting from chemotherapy.

The drug has a = long-term=20 effect, over 30 days.

"In some ways, you can = think of=20 chronic pain as the inability to turn off the memory = of the=20 pain. What=92s exciting is that we now may be = relieving what has=20 clinically been the most difficult to treat=97the = suffering or=20 the emotional component of pain." Apkarian said.=20

"Scientists have always tried to understand = pain from=20 the viewpoint of sensation. To control it, they tried = to stop=20 the sensory input to the brain. We are saying = there=92s a=20 cognitive memory and emotional component in the brain = that=20 seems abnormal. Easing that may have a bigger effect = on=20 suffering." he added.

Sensory abnormalities in = people=20 with chronic pain seem to be behind this memory = abnormality.=20 Roughly 10 % of the US population experiences chronic = pain,=20 mostly back pain.

Working with rats that had = chronic=20 pain from a healed limb injury, Apkarian found that = the=20 animals=92 emotional suffering dropped completely = while their=20 physical pain just by 30 %. Rats are nocturnal beings = that=20 prefer the dark to bright light. Researchers placed = the rats=20 in a two-compartment chamber: one side having light, = the other=20 being dark.

The team stimulated their = sensitive limbs=20 while they were in the dark side. The rats disliked = that and=20 retreated into the bright chamber. When treated with=20 D=96Cycloserine, the rats remained in the dark=20 chamber.

"Their aversive reaction to the = stimulation=20 disappeared. Based on the animal results, the next = step will=20 be to test the drug in clinical trials," Apkarian=20 said.

"When we do this in a clinical trial, we = expect=20 people to say I still have the pain, but it=92s not = bothering me=20 anymore. We think they will have a physical awareness = of the=20 pain, but its emotional consequences will have = decreased. The=20 drug potentially may lower the amount of standard = analgesics=20 people have to use." said Apkarian.

In 2006, = Apkarian=20 showed that chronic pains activate the prefrontal = cortex, such=20 as the discomfort of burning your finger, for example, = the=20 thalamus.
The longer a person has been suffering = from=20 chronic pain, the more activity will be seen in the = prefrontal=20 cortex.

"It=92s cumulative memory. I can = predict with 90=20 % accuracy how many years they have been living in = that pain=20 without even asking them the question." said Apkarian. =

Digg=20 this! Slashdot=20 it! Add to=20 del.icio.us Stumble! = ; Submit to=20 Reddit Add to=20 Technorati Furl PDF

MOR= E=20 RELATED ARTICLES: New Smart Painkillers The Gene of Cold = Sensation Newly Discovered Thai Bugs Devour=20 Fish Contact Lens Linked to Eye=20 Infection 10 Reasons to Move Nature's Viagra: Spider Venom Induces=20 Erection Magnets Boost Your Brain

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