From: Subject: Chronic Pain May Be Triggered By Old Memory Traces In Brain Date: Tue, 1 Apr 2008 10:26:48 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0096_01C893E2.E434D9E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0096_01C893E2.E434D9E0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.medicalnewstoday.com/articles/73100.php =EF=BB=BF Chronic Pain May Be Triggered By Old Memory = Traces In Brain
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Chronic Pain May Be Triggered By Old Memory Traces In Brain

Main = Category: Pain /=20 Anesthetics
Also Included In: B= iology /=20 Biochemistry;  Neurology / = Neuroscience
Article Date: 07 Jun 2007 - 18:00 PST

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Why do so many people continue to = suffer=20 from life-altering, chronic pain long after their injuries have actually = healed"=20

The definitive answer -- and an effective treatment -- has long = eluded=20 scientists. Traditional analgesic drugs, such as aspirin and morphine=20 derivatives, haven't worked very well.

A Northwestern University = researcher has found a key source of chronic pain appears to be an old = memory=20 trace that essentially gets stuck in the prefrontal cortex, the site of = emotion=20 and learning. The brain seems to remember the injury as if it were fresh = and=20 can't forget it.

With new understanding of the pain source, = Vania=20 Apkarian, professor of physiology, and of anesthesiology, at = Northwestern's=20 Feinberg School of Medicine, has identified a drug that controls = persistent=20 nerve pain by targeting the part of the brain that experiences the = emotional=20 suffering of pain. The drug is D-Cycloserine, which has been used to = treat=20 phobic behavior over the past decade.

In animal studies, = D-Cycloserine=20 appeared to significantly diminish the emotional suffering from pain as = well as=20 reduce the sensitivity of the formerly injured site. It also controlled = nerve=20 pain resulting from chemotherapy, noted Apkarian, who is a member of the = Robert=20 H. Lurie Comprehensive Cancer Center at Northwestern University. =

The=20 drug has long-term benefits. Animals appeared to be pain free 30 days = after the=20 last dose of a 30-day regime of D-Cycloserine.

The study, funded = by the=20 National Institutes of Health, will be published in the journal = Pain this=20 fall. (It has been published on-line.)

"In some ways, you can = think of=20 chronic pain as the inability to turn off the memory of the pain," = Apkarian=20 said. "What's exciting is that we now may be relieving what has = clinically been=20 the most difficult to treat - the suffering or the emotional component = of pain."=20

Scientists have always tried to understand pain from the = viewpoint of=20 sensation, Apkarian said. "To control it, they tried to stop the sensory = input=20 to the brain. "We are saying there's a cognitive memory and emotional = component=20 in the brain that seems abnormal. Easing that may have a bigger effect = on=20 suffering."

Chronic pain is not caused by a single mechanism, = Apkarian=20 noted. Sensory abnormalities in people with chronic pain probably drive = this=20 memory abnormality.

About 10 percent of the United States = population=20 suffers from chronic pain, of which the majority is back pain. =

One of=20 Apkarian's studies with rats tried to separately measure their emotional = suffering and their physical pain after being treated with the drug. = (The rats=20 had chronic pain from a healed limb injury.) The results indicated the = animals'=20 emotional suffering decreased much more than their physical pain. While = the=20 physical pain appeared to be reduced 30 percent - their emotional = suffering=20 completely disappeared.

Rat are nocturnal animals that prefer to = be in=20 the dark and are averse to bright light. Researchers placed the rats in = a=20 two-compartment chamber - one side light, one dark. When the rats were = in their=20 preferred dark side, scientists mechanically stimulated their sensitive = limbs.=20 The rats didn't like that and bolted into the bright chamber, where they = remained. Next scientists took the same rats and treated them with=20 D-Cycloserine. Again, scientists stimulated the rats' sensitive limbs. = This=20 time, however, the rats remained in the dark chamber.

"Their = aversive=20 reaction to the stimulation disappeared," Apkarian said.

Based = on the=20 animal results, the next step will be to test the drug in clinical = trials,=20 Apkarian said.

"When we do this in a clinical trial, we expect = people to=20 say I still have the pain, but it's not bothering me anymore," Apkarian = said.=20 "We think they will have a physical awareness of the pain, but its = emotional=20 consequences will have decreased." He said the drug potentially may = lower the=20 amount of standard analgesics people have to use.

In Apkarian's = previous=20 study, published in late 2006, he revealed that chronic back pain = appears in a=20 different part of the brain than the discomfort of burning your finger, = for=20 example. With a functional MRI, he found that chronic back pain shows up = in the=20 prefrontal cortex. By contrast, the acute sensory pain of the burned = finger=20 appears in the sensory part of the thalamus.

Apkarian also found = that=20 the longer a person has been suffering from chronic pain, the more = activity in=20 the prefrontal cortex. He was able to predict the years of their = suffering from=20 the MRI.

"It's cumulative memory," he explained. "I can predict = with 90=20 percent accuracy how many years they have been living in that pain = without even=20 asking them the question." =

----------------------------
Article=20 adapted by Medical News Today from original press=20 release.
----------------------------

Contact: Marla Paul =
Northwestern = University





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PADDING-BOTTOM: 20px; MARGIN: 0px = 2px 20px; BORDER-LEFT: #ddddff 1px solid; WIDTH: 220px; PADDING-TOP: = 1px; BORDER-BOTTOM: #ddddff 1px solid; BACKGROUND-COLOR: #ffffff } .fronttitles { BORDER-RIGHT: #000000 1px solid; PADDING-RIGHT: 4px; PADDING-LEFT: 4px; = FONT-SIZE: 12px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 4px; COLOR: = #ffffff; PADDING-TOP: 4px; BORDER-BOTTOM: #000000 1px solid } .fronttitles2 { BORDER-RIGHT: #000000 1px solid; PADDING-RIGHT: 4px; PADDING-LEFT: 4px; = FONT-SIZE: 12px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 4px; COLOR: = #ffffff; PADDING-TOP: 4px; BORDER-BOTTOM: #000000 1px solid } .fronttitles { BORDER-TOP: #74ce8e 1px solid; BORDER-LEFT: #74ce8e 1px solid; = BACKGROUND-COLOR: #00691e } .fronttitles2 { BORDER-TOP: #5a6bcf 2px solid; BORDER-LEFT: #5a6bcf 2px solid; = BACKGROUND-COLOR: #011696 } OPTION.option1 { BACKGROUND-COLOR: #f4f4ff } OPTION.option2 { BACKGROUND-COLOR: #ffffff } TEXTAREA { BORDER-RIGHT: #999999 1px solid; BORDER-TOP: #999999 1px solid; = 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PADDING-RIGHT: 5px; BORDER-TOP: #339900 1px solid; PADDING-LEFT: 5px; = BACKGROUND-IMAGE: url(/images/menubutton_right.jpg); PADDING-BOTTOM: = 5px; PADDING-TOP: 5px; BORDER-BOTTOM: #339900 1px solid; = BACKGROUND-REPEAT: repeat-y; BACKGROUND-COLOR: #ccffcc } .articlecatlist { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; WIDTH: 150px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } .articlecatlist LI { PADDING-BOTTOM: 1px; MARGIN: 0px; WIDTH: 148px; PADDING-TOP: 1px } .headertab1 { BORDER-RIGHT: #000000 1px solid; PADDING-RIGHT: 9px; BORDER-TOP: = #000000 1px solid; PADDING-LEFT: 8px; PADDING-BOTTOM: 9px; MARGIN: 0px = 0px 10px; BORDER-LEFT: #000000 1px solid; PADDING-TOP: 12px; = BORDER-BOTTOM: #ccffcc 1px solid; BACKGROUND-COLOR: #ccffcc; TEXT-ALIGN: = center } .headertab2 { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #999999 1px solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 7px; MARGIN: 0px = 0px 10px; BORDER-LEFT: #999999 1px solid; 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BORDER-RIGHT: #ddddff 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: = #ddddff 1px solid; PADDING-LEFT: 5px; FONT-SIZE: 11px; PADDING-BOTTOM: = 5px; MARGIN: 0px 0px 5px; BORDER-LEFT: #ddddff 1px solid; PADDING-TOP: = 5px; BORDER-BOTTOM: #ddddff 1px solid; BACKGROUND-COLOR: #ffffff; = TEXT-ALIGN: left } #newsvideo { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FLOAT: right; PADDING-BOTTOM: = 5px; WIDTH: 355px; PADDING-TOP: 5px; POSITION: relative; TEXT-ALIGN: = center } ------=_NextPart_000_0096_01C893E2.E434D9E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.medicalnewstoday.com/scripts/AntiSpambotMailto.js /**************************************************** AntiSpambotMailto() - Documentation and encoder at: http://www.kenric.com/AntiSpambotMailto.html ****************************************************/ function AntiSpambotMailto(codelist, description, atagattr) { var thiscode, thischar; var CodeString =3D new 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' ' + atagattr : ''; if (!description) description =3D AddrDecoded; // if no description = supplied, display email address var strOutput =3D '' + description + ''; document.write(strOutput); } /************************************************************************= *** Copyright (c) 2002 by Kenric L. Ashe - www.kenric.com - All rights = reserved. Redistribution and use in source and binary forms, with or without=20 modification, are permitted provided that the following conditions are = met: Redistributions of source code must retain the above copyright notice,=20 this list of conditions and the following disclaimer.=20 Redistributions in binary form must reproduce the above copyright = notice,=20 this list of conditions and the following disclaimer in the = documentation=20 and/or other materials provided with the distribution.=20 Neither the name of the Kenric.com nor the names of its contributors may = be used to endorse or promote products derived from this software = without=20 specific prior written permission.=20 THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS=20 "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT=20 LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR=20 A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT=20 OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,=20 SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED = TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR=20 PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF=20 LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING=20 NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS=20 SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. *************************************************************************= **/ ------=_NextPart_000_0096_01C893E2.E434D9E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://pagead2.googlesyndication.com/pagead/show_ads.js (function(){=0A= var = h=3D{google_ad_channel:"channel",google_ad_host:"host",google_ad_region:"= region",google_ad_section:"region",google_ad_type:"ad_type",google_adtest= :"adtest",google_alternate_ad_url:"alternate_ad_url",google_alternate_col= or:"alt_color",google_bid:"bid",google_city:"gcs",google_color_bg:"color_= bg",google_color_border:"color_border",google_color_line:"color_line",goo= gle_color_link:"color_link",google_color_text:"color_text",google_color_u= rl:"color_url",google_contents:"contents",google_country:"gl",=0A= google_cust_age:"cust_age",google_cust_ch:"cust_ch",google_cust_gender:"c= ust_gender",google_cust_id:"cust_id",google_cust_interests:"cust_interest= s",google_cust_job:"cust_job",google_cust_l:"cust_l",google_cust_lh:"cust= _lh",google_cust_u_url:"cust_u_url",google_disable_video_autoplay:"disabl= e_video_autoplay",google_ed:"ed",google_encoding:"oe",google_feedback:"fe= edback_link",google_flash_version:"flash",google_gl:"gl",google_hints:"hi= nts",google_kw:"kw",google_kw_type:"kw_type",google_language:"hl",=0A= google_referrer_url:"ref",google_region:"gr",google_reuse_colors:"reuse_c= olors",google_safe:"adsafe",google_targeting:"targeting",google_ui_featur= es:"ui"},m=3D{google_ad_format:"format",google_ad_output:"output",google_= ad_callback:"callback",google_ad_override:"google_ad_override",google_ad_= slot:"slotname",google_analytics_uacct:"ga_wpids",google_correlator:"corr= elator",google_cpa_choice:"cpa_choice",google_image_size:"image_size",goo= gle_last_modified_time:"lmt",google_max_num_ads:"num_ads",google_max_radl= ink_len:"max_radlink_len",=0A= google_num_radlinks:"num_radlinks",google_num_radlinks_per_unit:"num_radl= inks_per_unit",google_only_ads_with_video:"only_ads_with_video",google_pa= ge_location:"loc",google_page_url:"url",google_rl_dest_url:"rl_dest_url",= google_rl_filtering:"rl_filtering",google_rl_mode:"rl_mode",google_rt:"rt= ",google_skip:"skip"};function n(b){return h[b]||m[b]||null};function = r(){}r.prototype.e=3Dfunction(){};r.prototype.m=3Dfunction(){};r.prototyp= e.P=3Dfunction(){};var s=3Dnull;function = v(){this.b=3Dthis.M();this.p=3Dfalse;if(!this.b){this.p=3Dthis.C();if(!th= is.p)s.m("Browser does not allow = cookies")}}v.prototype.n=3D"__gads=3D";v.prototype.f=3D"GoogleAdServingTe= st=3D";v.prototype.G=3Dfunction(){return = this.b};v.prototype.setCookieInfo=3Dfunction(b){this.a=3Db._cookies_[0];i= f(this.a!=3Dnull){this.b=3Dthis.a._value_;this.O()}};v.prototype.F=3Dfunc= tion(b){var a=3D(new Date).valueOf(),c=3Dnew Date;=0A= c.setTime(a+b);return = c};v.prototype.D=3Dfunction(b){if(this.b!=3Dnull||!this.p){s.e("Skipping = fetch cookie call");return}var = a=3Ddocument.domain,c=3D"http://partner.googleadservices.com/gampad/cooki= e.js?callback=3D_GA_googleCookieHelper.setCookieInfo&client=3D"+y(b)+"&do= main=3D"+y(a);s.e("Issuing a fetch cookie call with "+c+"");document.write("