August 10, 1999, Tuesday
A Munch Moment By SHERWIN B. NULAND
FOR a brief period during my years of surgical training in the
late 1 950's, I worked under a tough-minded senior resident who
conducted what he called "narcotic rounds" every evening
just before midnight. The purpose of the former Army medic's solitary
nocturnal perambulations through the wards was to decrease, or sometimes
cancel, the dosages of post-operative pain medication junior members
of his team had ordered during the day. Should any of us have the
temerity to reinstate those dosages the following morning, the miscreant
was sure to be subjected to a string of invective, "lily livered"
being the least indelicate of the terms he used. The ax-sergeant's
message to us was that all complaints of pain were exaggerated,
if not phony.
One day, 20 years later, a nurse refused to administer the Demerol
I had ordered for a patient with advanced cancer, pointing out that
the dosage was significantly higher than usual and the frequency
approximately twice what was recommended in the hospital drug manual.
She and the head nurse who supported her decision could not be persuaded
to relent, even when I remonstrated that the prescribed amount was
standard in our local hospice. It took the intervention of their
supervisor to convince them that the patient's pain could not otherwise
be brought under control.
More than a decade would pass before an increasing body of literature
on symptom relief made it clear that pain is commonly undertreated
in American hospitals. Recently, two scientists at the New York
State University in Albany were granted a patent for a computerized
system of measuring pain. Whether or not it is effective remains
to be seen.
The two reasons most often cited for patients suffering pain unnecessarily
involve the patients themselves and the professionals who care for
them. It must have come as a disagreeable surprise to my obdurate
former resident when he read in one journal after another that many
sick people are too stoic for their own good, or at least reluctant
to ask for sufficient relief lest they be thought not stoic enough.
Physicians and nurses underestimate the severity of pain, particularly
when it is at its most intense. Comprehending the magnitude of pain
that accompanies some medical conditions is very difficult for those
who have not themselves suffered. Samuel Johnson, a man accustomed
to discomforts of all sorts, said 250 years ago, "Those who
do not feel pain seldom think that it is felt."
AMONG the several difficulties inherent in the misapprehensions
about the treatment of pain is the troublesome fact that there has
never been any accurate way to measure its severity. Neurologists
and researchers depend on rather simplistic pain intensity scales
based on patients' verbal reports or the choice they make from a
graded sequence such as 1 to 10 or its equivalent. The situation
is far from ideal.
But all of this is said to be changing with the new method developed
by Dr. A. Vania Apkarian, a neuroscientist at SUNY's Upstate Medical
University in Syracuse, and Dr. Nikolaus Szeverenyi, a radiological
physicist at SUNY in Albany. Volunteers in their studies are subjected
to varying degrees of discomfort, and their brains' responses are
recorded on an electroencephalogram or imaged by a C.T. scan or
M.R.I. But even with such a complex assortment of electronic gadgetry,
results depend ultimately on the subjects' description of the degree
of pain they feel, which is signaled by how far they separate their
opposed thumb and forefinger. The researchers believe that they
can correlate the characteristics of the brain patterns with the
quantity of pain the patient reports in such a way that the images
or electroencephalographic tracings can then be used as an unbiased
and therefore; accurate indicator of a patient's discomfort. Interpretations
made in this way, the patent document states, create a "quantitative
analysis to characterize the brain's representation of pain."
Sounds good, doesn't it? The trouble is that the more experience
physicians have with the diagnosis and treatment of pain, the more
skeptical they are likely to be about the usefulness of the newly
developed technology. There is a reason for the present lack of
objectivity in pain measurement: The quality measured is in itself
not objective. For example, a pinprick delivered with a measurable
amount of pressure will produce widely differing perceptions among
a group of subjects of differing personality characteristics, or
even when applied at different times in the same individual, as
surrounding conditions change or even as mood alters. We feel pain
in various ways at various times, depending on who we are and the
circumstances under which it occurs. Not only that, but even were
it possible to make the perceptions exactly the same among a diverse
group of people, the ability of each to tolerate similar degrees
of perceived pain would vary considerably. In other words, both
the amount of pain one feels and the ability to tolerate it are
the result of a mix of factors, the subjective or intangible among
which are at least as significant as the physical or chemical.
THE symptom of pain has multiple dimensions. Its diagnosis, measurement
and treatment are so complex that scientists and clinicians in vast
numbers have turned their attention to its many aspects, and organized
themselves in the International Association for the Study of Pain.
Even the meaning of the word is entangled with uncertainty, and
the group has constructed a working definition: "an unpleasant
sensation and emotional experience associated with either actual
or potential tissue damage, or described in terms of such damage."
This means that those most qualified to study pain recognize it
not only as a "sensation" but also as an "emotional
experience," including the realization that even the "sensation"
part of it is to a large extent determined by the emotional circumstances
in which it occurs. Patent or no patent, it will be decades before
the technology is developed that can reliably quantify emotion and
measure its contribution to the calculus of-a sick person's pain.
The old sergeant died about 10 years ago. I am told that he bore
a difficult final illness with forebearance and a determination
not to show outward signs of suffering. I hope his doctors and nurses
were more sensitive than he had been. I hope they went to great
lengths to relieve the anguish of body and mind that he was never
able to acknowledge, whether in himself or others.
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